Regorafenib is to treat cancer of the colon and rectum (colorectal cancer) that has spread to other organs. It is also used to treat certain cancers of the digestive system (gastrointestinal stromal tumor ). Talking about Regorafenib 40 mg Cost in UK, it is quite costly. Also, you cannot buy it randomly at any store. The drug works by slowing or stopping the growth of cancer cells. Regorafenib comes under the trade is Stivarga.

Regorafenib 40 mg tablet Cost in UK

Regorafenib 40 mg tablet Cost in UK is not quite pocket-friendly so many patients seek to get it directly from India. If you wish to buy Regorafenib online from us then you are just a few step away. You can simply fill the side contact form or you can directly write to us via WhatsApp or email. We will get back to you soonest with our best affordable price. Since, we are shipping to worldwide so you can buy it easily on prescription.

How should I take Regorafenib?

Take the medicine with a low-fat meal as directed by your doctor. Normally, according to a treatment cycle, you will take the drug once a day for 21 days, then stop taking it for 7 days and continue taking it this way as directed by your doctor. When taking, you will not crush, chew or split the tablet, but swallow the tablet whole.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or use this medicine more often or for longer than directed. Your condition will not improve any faster and there is an increased risk of serious side effects.

You need to take this medicine regularly to get the best effect from it. Remember to take your medicine at the same time each day as your dosing schedule.

You should avoid eating grapefruit or drinking grapefruit juice while taking this medicine, unless your doctor or pharmacist thinks it is safe to do so. Grapefruit may increase your risk of side effects from this medicine. Ask your doctor or pharmacist for more details. 

Because this medicine can be absorbed through the skin and lungs, which could harm an unborn baby, pregnant women or people who may become pregnant should not come into contact with or breathe in the dust.

How should Regorafenib be stored?

You should store at room temperature, away from moisture and light. Do not store in the bathroom or in the freezer. You should keep in mind that each medicine may have different storage methods. Therefore, you should carefully read the storage instructions on the packaging, or ask the pharmacist. Keep medicine out of reach of children and pets.

You should not throw medicine down the toilet or plumbing unless told to do so. Instead, dispose of medication properly when it is past its expiration date or cannot be used. You can consult your pharmacist or local waste disposal company about how to safely dispose of your medication. You also need to throw away any unused pills 28 days after opening the vial. 

Dosage

The information provided is not a substitute for medical professional advice. Always consult your doctor or pharmacist before deciding to take a medication.

What is the adult dose of Regorafenib?

Usual Adult Dose for Colorectal Cancer:

Initial dose: 160 mg (4 40 mg tablets) orally once a day for the first 21 days of each 28-day cycle.

Duration of treatment: you continue treatment until the disease progresses or the toxicity cannot be controlled.

Usual adult dose for gastrointestinal stromal tumor:

Initial dose: 160 mg (4 40 mg tablets) orally once a day for the first 21 days of each 28-day cycle.

Duration of treatment: you continue treatment until the disease progresses or the toxicity cannot be controlled.

What is the dose of Regorafenib for children?

Dosage for children has not yet been studied and decided. Consult your doctor if you are giving this medicine to a child.

What forms and strengths does Regorafenib come in?

Regorafenib is available in the following forms and strengths: 40 mg tablets. 

What are the side effects of taking Regorafenib?

Call 911 right away if you have any of these signs of an allergic reaction: hives; shortness of breath; swelling in the face, lips, tongue, or throat.

• Stop using Regorafenib and call your doctor at once if you have:
• fever, chills, flu symptoms, sore mouth, severe vomiting or diarrhea ;
• Feeling very thirsty or hot, unable to urinate, sweating a lot, hot and dry skin;
• Blood in the urine or stools, coughing up blood or vomit that looks like coffee grounds ;
• Prolonged menstrual cycles or unusual vaginal bleeding;
• Bleeding that cannot be stopped;
• chest pain and severe dizziness, fainting, feeling short of breath;
• headache, confusion, altered mental status, loss of vision, seizures (convulsions);
• Pain in the upper abdomen, itching, loss of appetite, dark urine, clay-colored stools, jaundice;
• Dangerously high blood pressure (blurred vision, ringing in the ears , anxiety, irregular heartbeat);
• rash, blisters, oozing, or severe pain in the palms of your hands or soles of your feet;
• Have any wound that cannot be healed;
• Severe skin allergy–fever, sore throat, swelling of the face or tongue, burning eyes , skin pain with a red or purple skin rash that spreads (especially to the face or upper body) and causes blistering and sloughing.

Common side effects may include:

• Diarrhea, abdominal pain, weight loss;
• Hoarse voice ;
• Feeling weak or tired.
• Not everyone experiences these side effects. There may be other side effects not mentioned. If you have any questions about side effects, consult your doctor or pharmacist.

What should you know before taking Regorafenib?

Before using the drug, you should pay attention to the following issues:

• Tell your doctor and pharmacist if you are allergic to Regorafenib, any other medications, or any of the ingredients in Regorafenib tablets. Ask your pharmacist for a list of the ingredients in the pill. 
• Tell your doctor and pharmacist about any other prescription and nonprescription drugs, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants such as warfarin (Coumadin®); some antifungal medicines such as itraconazole (Sporanox®), ketoconazole (Nizoral®), posaconazole (Noxafil®), and voriconazole (Vfend®); certain seizure medications such as carbamazepine (Carbatrol®, Epitol®, Tegretol®), phenobarbital , phenytoin (Dilantin®, Phenytek®); clarithromycin (Biaxin®, in Prevpac®); irinotecan (Camptosar®); rifampin ( Rifadin® , Rifamate®, in Rifater®); telithromycin ( Ketek® .)). Your doctor may need to change the dose of your medicine or carefully monitor side effects.
• Tell your doctor what herbal products you are taking, especially St. John wort. You should not use St. John’s wort while taking Regorafenib.
• Tell your doctor if you have a wound that has not healed or if you have or have ever had bleeding problems, high blood pressure, heart disease, kidney disease, or liver disease. Also,
• tell your doctor if you have just had surgery.
• Tell your doctor if you are pregnant or plan to become pregnant, or if you plan to become a father. You or your sexual partner should not become pregnant while taking Regorafenib and for 2 months after stopping treatment. You should consult your doctor about effective birth control methods for you. If you or your sex partner becomes pregnant while taking Regorafenib or within 2 months of stopping it, call your doctor. Regorafenib can harm an unborn baby.
• Tell your doctor if you are breast-feeding. 
• If you are having surgery, including dental surgery, tell your doctor or dentist that you are taking Regorafenib. Your doctor will likely tell you to stop taking Regorafenib at least 2 weeks before surgery. Your doctor will tell you when it is safe to start taking Regorafenib again after surgery.
• You should be aware that blood pressure may increase during treatment with Regorafenib. Your doctor will need to check your blood pressure during treatment.

Things to keep in mind if you are pregnant or breastfeeding

There are not enough studies to determine the risks of taking this medicine during pregnancy or breast-feeding. Before taking medication, always consult with your doctor to weigh the benefits and risks.

According to the United States Food and Drug Administration (FDA), this drug belongs to the category D drug for pregnancy. You can refer to the table of drugs used for pregnant women below: 

A = No risk;
B = No risk in some studies;
C = Possible risk;
D = There is evidence of risk;
X = Contraindications;
N = Don’t know yet.

What drugs can interact with Regorafenib?

Drug interactions can change how a drug works or increase the effect of side effects. This document does not cover all possible drug interactions. It is best to write down a list of all the medicines you are taking (including prescription, nonprescription and dietary supplements) and show them to your doctor or pharmacist. Do not self-medicate, stop or change the dosage of the drug without your doctor’s approval.

• anticoagulants (eg warfarin) – as this may increase the risk of bleeding;
• Cobicistat, fluconazole, itraconazole, ketoconazole, macrolide antibiotics (eg azithromycin, clarithromycin), mifepristone , nefazodone, posaconazole, protease inhibitors (eg boceprevir, ritonavir), telithromycin or voriconazole – because these drugs can increases the risk of side effects from Regorafenib;
• Carbamazepine, enzalutamide, hydantoins (eg, phenytoin), phenobarbital, primidone, rifamycins (eg rifampin), or St. John wort – as they may decrease the effectiveness of Regorafenib.

Can food and alcohol interact with Regorafenib?

Consult your health professional about taking your medicine with food, alcohol and tobacco.

1. Grapefruit juice.

What medical conditions affect Regorafenib?

Your medical condition may affect the use of this medicine. Tell your doctor if you have any health problems, especially:

• Bleeding problems;
• Heart disease (eg myocardial infarction );
• Hypertension (high blood pressure);
• Liver disease – use with caution as symptoms may be aggravated by slower elimination from the body. 

What should you do in case of an emergency or overdose?

In the event of an emergency or overdose, call 911 immediately or go to the nearest local health station.

Overdose symptoms may include:

• Rash or other changes in the skin;
• Voice change or hoarseness;
• Diarrhea;
• Swelling inside the nose or mouth;
• Dry mouth;
• Anorexia;
• Tired.

Missed Dose

If you forget to take a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take double the prescribed dose. 

Price of Regorafenib Capsule & Buy Online

You can buy generic Regorafenib in UK from India at the best price on prescription. If you are interested in buying Regorafenib online and want to know the discounted price of Regorafenib in UK, please contact us via WhatsApp for quick assistance or fill out the inquiry form below to get the best current price. Doctor prescription is mandatory for this medicine. We are shipping worldwide.